The Abbott lab uses a systems biology approach to better understand the molecular pathogenesis of Inflammatory Disease.  These diseases include Crohn's Disease and Sarcoidosis.  These diseases are enigmatic, and we hope that hoped that by better understanding the molecular mechanisms of their pathogeneisis through global approaches, better treatments might be acheived.

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Positions Available

We are always looking for graduate students and post-doctoral fellows.  Prior experience is not necessary, however people with a curiosity about science, a willingness to work hard and a fun-loving personality are always encouraged to join us.
NOD2 Signaling

Systems Biology
Mouse Models of Inflammatory Disease

Room 6533 Wolstein Research Building,  2103 Cornell Road, Cleveland, OH   44106

Systems Biology of Inflammatory Disease
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We are interested in determining the molecular mechanisms by which the Crohn's Disease and Sarcoiosis susceptibility gene, NOD2, signals.
We use Next-Gen sequencing technology, bioinformatics and proteomic approaches to better understand signaling pathways altered in inflammatory disease
We use itchy mice and a mouse knockin containing a non-ubiquitinatable form of NEMO to model in inflammatory disease.
Front Row: Steven Chirieleison, Jessica Perez, Derek Abbott
Middle Row: Janice Jun, Sylvia Kertesy
Back Row: Justine Tigno-Aranjuez